CAS NO 17372-87-1 Eosin Y powder

Product Name:

EOSIN

Synonyms:

disodium 2-(2,4,5,7-tetrabromo-6-oxido-3-oxoxanthen-9-yl)benzoate;waterred2;Eosin Disodium;AKA230(1);AKA230(2);RED 21 LAKE;EOSIN Y, INDICATOR GRADE;EOSIN Y, 5 WT. % SOLUTION IN WATER

CAS:

17372-87-1

MF:

C20H6Br4Na2O5

MW:

691.85418

EINECS:

241-409-6

Product Categories:

Inhibitors;Fluorescent;Dyes and Pigments;Organics;M;Xanthene;Stains and Dyes;Stains&Dyes, A to;Hematology and Histology;Hematology Stains;Fluorescent Labels;Fluorescent Probes, Labels, Particles and Stains;Other Fluorescent Labels

Mol File:

17372-87-1.mol

Melting point

>300°C

density

1.02 g/mL at 20 °C

vapor pressure

0Pa at 25℃

Fp

11 °C

storage temp.

Store at RT.

solubility

H2O: 0.1 g/mL, dark red

Colour Index

45380

pka

2.9, 4.5(at 25℃)

form

Solid

color

Reddish

PH

9.2 (10g/l, H2O, 20℃)

PH Range

0(yellow)-3(green fluoresc.)

Water Solubility

freely soluble

λmax

514nm

Merck

14,3603

BRN

3586809

Stability:

Stable. Incompatible with strong oxidizing agents.

Biological Applications

Treating age-related macular degeneration,burns,cancer,diabetes,obesity,dental bone defects,gastroesophageal reflux disease,prostate cancer,viral diseases; stents; wound-healing materials

Major Application

Photovoltaic devices, color filter, nanoscale host material, detection of latent fingerprints, inks, detergents, hair dyes, cosmetics, implantable drug delivery devices, stents, diagnosis of breast lesions, labeling nucleic acids, detecting proteins, stress biomarkers, phosphoprotein, breast cancer metastases, antimicrobial agent, treatment of burns, endodontic, diabetes, obesity, cancer, radiochemotherapy, DNA sequencing, gene expression profiling, wound healing promoters

LogP

-1.33

CAS DataBase Reference

17372-87-1(CAS DataBase Reference)

EPA Substance Registry System

Eosin Yellowish (YS) (17372-87-1)

Chemical Properties

brownish-red powder

Uses

Eosin is most often used as a counterstain to haematoxylin in H&E (haematoxylin and eosin) staining. H&E staining is one of the most commonly used techniques in histology.

Uses

Anti Septic

Uses

Eosin Yellowish noted to reduce the affinity of Mg2+-ATPase for ATP and increase the enzyme affinity for Mg2+ at concentrations of 10-50 ?M. At higher concentrations near 100 ?M the affinity for Mg2+-ATPase for the ion-activator has been shown to be reduced. This compound has also been reported to be a photosensitizer that works as a molecular photoelectrode via catalyzation of the visible-light-driven electron-transfer reaction. Eosin Y is also used to stain structures such as muscle, cytoplasm, and collagen. This agent also enhances fluorescent quenching abilities by forming a complex with polyvinulpyrrolidone.

Preparation

countries called red. Fluorescent element (C.I. Acid Yellow 73, C.I. 45350) in water or ethanol solution bromine into four bromine derivatives, and then into sodium salt.

Definition

ChEBI: An organic sodium salt that is 2',4',5',7'-tetrabromofluorescein in which the carboxy group and the phenolic hydroxy group have been deprotonated and the resulting charge is neutralised by two sodium ions.

Flammability and Explosibility

Not classified

Biological Activity

ami5/eosin y disodium salt is a non-selective protein methyltransferase inhibitor.post-translational protein methylation at lysine and arginine residues is related to the gene expression regulation. the enzymatic activities of protein methyltransferases serve to do covalent modifications in the control of gene transcription.

Safety Profile

Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion. Questionable carcinogen with experimental tumorigenic data. When heated to decomposition it emits very toxic fumes of Brand NazO. See also BROMIDES.

in vitro

ami5/eosin y disodium salt has been identified as a competitive inhibitor of sam binding and had been shown to inhibit not only prmts but also lysine methylation by the set7 and disruptor of telomeric silencing 1-like (dot1l) mtases in vitro. both ami5/eosin y disodium salt and its analog ami-1 have been used as lead compounds for the development of novel mtase-specific inhibitors. moreover, it was found that ami5/eosin y disodium salt could inhibit set7 in vitro and decrease h3k4m1 in vascular endothelial cells. [1].

IC 50

0.78 and 1.41 μm for hmt1p and prmt1, respectively

storage

+4°C

Purification Methods

Dissolve it in the minimum volume of H2O (1g/mL), filter and add EtOH until separation of salt is complete. Filter the solid off, wash it with absolute EtOH, then Et2O and dry it first in air, then at 100o. It is used for staining blood cells and for estimating traces of Ag. [Selsted & Becker Anal Biochem 155 270 1986, El-Ghamry & Frei Anal Chem 40 1986 1968.] [Beilstein 19 III/IV 2917.] [See above]