3-Isobutyl-1-Methylxanthine Fine Chemicals,
28822-58-4 Fine Chemicals
IBMX CAS 28822-58-4 Industrial Fine Chemicals 3-ISOBUTYL-1-METHYLXANTHINE
|3-ISOBUTYL-1-METHYLXANTHINE Basic information|
|3-ISOBUTYL-1-METHYLXANTHINE Chemical Properties|
|Melting point||200-201 °C(lit.)|
|Boiling point||363.42°C (rough estimate)|
|density||1.2042 (rough estimate)|
|refractive index||1.6500 (estimate)|
|solubility||DMSO: 1 M with gentle warming|
|Stability:||Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.|
|CAS DataBase Reference||28822-58-4(CAS DataBase Reference)|
3-Isobutyl-1-methylxanthine, also known as IBMX, is a chemical compound belonging to the xanthine family. It is a white crystalline powder that is commonly used in research and pharmaceutical applications. Here are some key points about 3-Isobutyl-1-methylxanthine:
Structure and Properties: 3-Isobutyl-1-methylxanthine has a molecular formula of C₁₀H₁₄N₄O₂ and a molecular weight of 222.24 g/mol. It has a xanthine core structure with an isobutyl group (CH₃CH(CH₃)CH₂-) attached at the 3-position and a methyl group (-CH₃) at the 1-position.
Pharmacological Effects: IBMX is a non-selective phosphodiesterase (PDE) inhibitor. It acts by blocking the activity of PDE enzymes, which are responsible for the breakdown of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). By inhibiting PDE, IBMX increases the levels of cAMP and cGMP, leading to various physiological effects such as vasodilation, smooth muscle relaxation, and increased neurotransmitter release.
Research Applications: IBMX is widely used in scientific research, particularly in the fields of pharmacology, cell biology, and neuroscience. It is often employed to elevate intracellular cAMP and cGMP levels, which can modulate cellular signaling pathways and influence cellular functions. IBMX is commonly used as a positive control or reference compound in experiments involving cyclic nucleotides.
Pharmaceutical Applications: Due to its PDE inhibitory activity, IBMX has been investigated for its therapeutic potential in various medical conditions. It has been studied for its effects on respiratory diseases, cardiovascular disorders, and central nervous system disorders. Additionally, IBMX is used to enhance the efficiency of in vitro fertilization (IVF) by preventing the degradation of cAMP in oocytes.
Safety and Precautions: As with any chemical compound, proper handling and safety precautions should be followed when working with 3-Isobutyl-1-methylxanthine. It is important to consult material safety data sheets (MSDS) and follow the guidelines provided by suppliers. IBMX should be stored in a cool, dry place away from direct sunlight and incompatible substances.
Please note that while the information provided here is accurate to the best of my knowledge, it is always recommended to consult authoritative sources and scientific literature for specific details and applications of 3-Isobutyl-1-methylxanthine.
Contact Person: Maggie Ma
Tel: +0086 188 7414 9531