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CAS 18883-66-4 STZ Streptozotocin 98% N-(Methylnitrosocarbamoyl)-α-D-glucosamine

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CAS 18883-66-4 STZ Streptozotocin 98% N-(Methylnitrosocarbamoyl)-α-D-glucosamine

CAS 18883-66-4 STZ Streptozotocin 98% N-(Methylnitrosocarbamoyl)-α-D-glucosamine
CAS 18883-66-4 STZ Streptozotocin 98% N-(Methylnitrosocarbamoyl)-α-D-glucosamine CAS 18883-66-4 STZ Streptozotocin 98% N-(Methylnitrosocarbamoyl)-α-D-glucosamine

Large Image :  CAS 18883-66-4 STZ Streptozotocin 98% N-(Methylnitrosocarbamoyl)-α-D-glucosamine

Product Details:
Place of Origin: China
Brand Name: YunbangPharm
Certification: ISO9001/SGS
Model Number: YB135
Payment & Shipping Terms:
Minimum Order Quantity: To Be Negotiated
Price: To Be Negotiated
Packaging Details: 1g 5g 25g
Delivery Time: 3-7 Working Days
Payment Terms: L/C, D/A, D/P, T/T, Western Union

CAS 18883-66-4 STZ Streptozotocin 98% N-(Methylnitrosocarbamoyl)-α-D-glucosamine

Description
Name: Streptozotocin CAS: 18883-66-4
Form: Powder Color: White To Light Yellow
Storage Temp.: −20°C

 

CAS 18883-66-4 STZ Streptozotocin 98% N-(Methylnitrosocarbamoyl)-α-D-glucosamine

 

General description

Streptozocin (STZ) is an antineoplastic antibiotic. This N-nitroso-containing compound acts as a nitric oxide donor in pancreatic islets. It is a methylnitrosourea attached to a single molecule of glucosamine and has a high affinity for the cell surface glucose transporter glucose transporter type 2 (GLUT2), which is highly expressed on beta cells of the islets of Langerhans.Streptozotocin cannot pass through the blood-brain barrier, but its metabolites are usually seen in the cerebrospinal fluid.

In cell culture medium, it has been shown to have a biological half-life of approximately 19 minutes. It is a strong methylating agent that interacts with DNA in vitro to produce methylated purines. It can impact glucose metabolism because STZ is particularly toxic to the insulin-producing beta cells of the pancreas in mammals and is also an effective antibiotic against Gram-negative bacteria. It inhibits the synthesis of DNA in microorganisms and mammalian cells by alkylation and cross-linking the strands of DNA and affects all stages of the mammalian cell cycle. STZ is considered mutagenic, carcinogenic, and possibly teratogenic in humans. It is cytotoxic to the neuroendocrine tumor cell lines that express the GLUT2 glucose transporter.
 

Application

Streptozocin or streptozotocin is used to induce type 1 diabetes for medical research.
 

 

Basic information
Product Name: Streptozotocin
CAS: 18883-66-4
MF: C8H15N3O7
MW: 265.22
EINECS: 242-646-8
Streptozotocin Structure
 
Streptozotocin Chemical Properties
Melting point 121 °C (dec.) (lit.)
alpha D25 +39°
Boiling point 408.44°C (rough estimate)
density 1.4410 (rough estimate)
refractive index 1.6500 (estimate)
storage temp. -20°C
solubility Soluble in DMSO (up to 25 mg/ml) or in Water (up to 25 mg/ml)
form powder
pka pKa 1.3 (Uncertain)
color white to light yellow
Water Solubility soluble
Sensitive Hygroscopic
Merck 13,8912
BRN 2060675
Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.
   
   
   
   

 CAS 18883-66-4 STZ Streptozotocin 98% N-(Methylnitrosocarbamoyl)-α-D-glucosamine 1

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