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CAS 3952-78-1 Alizarin-3-Methyliminodiacetic Acid

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CAS 3952-78-1 Alizarin-3-Methyliminodiacetic Acid

CAS 3952-78-1 Alizarin-3-Methyliminodiacetic Acid
CAS 3952-78-1 Alizarin-3-Methyliminodiacetic Acid CAS 3952-78-1 Alizarin-3-Methyliminodiacetic Acid

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Product Details:
Place of Origin: China
Brand Name: YunbangPharm
Certification: ISO9001
Model Number: YB079
Payment & Shipping Terms:
Minimum Order Quantity: Negotiable
Price: Negotiable
Packaging Details: 1kg/Bottle, 5-25kg/Drum
Delivery Time: 5-8 working days
Payment Terms: L/C, D/A, D/P, T/T, Western Union
Supply Ability: 10Ton/Month

CAS 3952-78-1 Alizarin-3-Methyliminodiacetic Acid

Product Name: Alizarin-3-methyliminodiacetic Acid Cas No: 3952-78-1
Molecular Formula: C19H15NO8 EINECS: 223-544-2
Colour: Brown Boiling Point: ~185 °C (dec.)
Melting Point: 511.79°C (rough Estimate) Form: Powder
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Alizarin-3-Methyliminodiacetic Acid


CAS 3952-78-1 Biological Buffers

CAS 3952-78-1 Alizarin-3-methyliminodiacetic acid
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Synonyms:(((3,4-dihydroxy-2-anthraquinonyl)methyl)imino)di-aceticaci;[(3,4-Dihydroxy-2-anthraquinonyl)methyl]iminod;1,2-dihydroxy-anthrachinon-3-methylen-iminodiessigsaeure;Alizarin Fluorine Blue test solution(ChP);2-[carboxymethyl-[(3,4-dihydroxy-9,10-dioxo-2-anthracenyl)methyl]amino]acetic acid;ALIZARIN COMPLEXONE;Aizarin-3-methylamine-N,N-diaceticacid;Alizarincompiexone
Product Categories:Photometric Reagents (Complexone);Analytical Chemistry;Anthraquinones;Chelating Reagents;Complexones;Hydroxyanthraquinones
Mol File:3952-78-1.mol
Melting point~185 °C (dec.)
Boiling point511.79°C (rough estimate)
density1.4951 (rough estimate)
refractive index1.5000 (estimate)
storage temp.2-8°C
solubilityDMF: 10 mg/ml; DMSO: 10 mg/ml; DMSO:PBS (pH 7.2) (1:7): 0.125 mg/ml
formFine Powder
Water SolubilitySlightly soluble (0.2 g/L)
Stability:Incompatible with strong oxidizing agents.
CAS DataBase Reference3952-78-1(CAS DataBase Reference)
EPA Substance Registry SystemGlycine, N-(carboxymethyl)-N-[(9,10-dihydro-3,4-dihydroxy-9,10-dioxo-2-anthracenyl)methyl]- (3952-78-1)
DescriptionAlizarin-3-methyliminodiacetic acid is a colorimetric dye for the detection of fluoride ions. It reacts with fluoride to form a lilac-blue complex which can be quantified colorimetrically at 620 nm to determine fluoride concentration. Alizarin-3-methyliminodiacetic acid has been used to visualize fluoride deposition and bone mineralization during development in medaka larvae. It is also an inhibitor of inducible nitric oxide synthase (iNOS; IC50 = 35 nM).
Chemical PropertiesBrown-orange crystals, insoluble in water
UsesAlizarin is the main ingredient for the manufacture of the madder lake pigments known to painters as Rose madder and Alizarin crimson. A notable use of alizarin in modern times is as a staining agent in biological research because it stains free calcium and certain calcium compounds a red or light purple color. Alizarin Red is used in a biochemical assay to determine, quantitatively by colorimetry, the presence of calcific deposition by cells of an osteogenic lineage.
UsesAlizarin Complexone is used for the determination of fluorine and other anions. ATA is also a potent inhibitor of protein-nucleic acid interactions.
UsesAlizarin-3-methyliminodiacetic acid has been used:
  • for live staining of mineralized bone matrix
  • to double-label the bone for dynamic bone histomorphometry at the femoral mid-diaphysis in the rat
  • as a label in histomorphometry of the tibial diaphysis to indicate new bone formation in the rat
DefinitionChEBI: A dihydroxyanthraquinone compound in which the hydroxy groups are at C-1 and C-2 and which has a bis[(carboxymethyl)amino]methyl substituent at the 3-position.
General DescriptionAlizarin-3-methyliminodiacetic acid is used in the colorimetric detection of fluorine. It is a dye employed to stain mineralized bones of the preserved specimen from vertebrates.
HazardAnthraquinones are toxic by ingestion: vomiting, diarrhea, kidney and liver damage, and coma;
Deaths have been reported after children ingested Rhamnus berries;
Has antiretroviral activity;
An irritant;
Harmful by ingestion, inhalation, or skin absorption;
Toxic if swallowed.
Purification MethodsIt is purified by suspending it in 0.1M NaOH (1g in 50mL), filtering the solution and extracting alizarin with 5 successive portions of CH2Cl2. Then add HCl dropwise to precipitate the reagent, stirring the solution in an ice bath. Filter the precipitate onto a glass filter, wash it with cold water and dry it in a vacuum desiccator over KOH [Ingman Talanta 20 135 1973, Beilstein 14 IV 931].
CAS 3952-78-1 Alizarin-3-Methyliminodiacetic Acid 1
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CAS 3952-78-1 Alizarin-3-Methyliminodiacetic Acid 4

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