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CAS 50-07-7 Mitomycin C Antibiotic Raw Materials MF C15H18N4O5

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CAS 50-07-7 Mitomycin C Antibiotic Raw Materials MF C15H18N4O5

CAS 50-07-7 Mitomycin C Antibiotic Raw Materials MF C15H18N4O5
CAS 50-07-7 Mitomycin C Antibiotic Raw Materials MF C15H18N4O5 CAS 50-07-7 Mitomycin C Antibiotic Raw Materials MF C15H18N4O5 CAS 50-07-7 Mitomycin C Antibiotic Raw Materials MF C15H18N4O5

Large Image :  CAS 50-07-7 Mitomycin C Antibiotic Raw Materials MF C15H18N4O5

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Place of Origin: China
Brand Name: YunbangPharm
Certification: ISO9001/SGS
Model Number: YB140
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Packaging Details: 5mg 25mg 100mg
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CAS 50-07-7 Mitomycin C Antibiotic Raw Materials MF C15H18N4O5

Description
Name: Mitomycin C CAS: 50-07-7
Reaxys Registry Number: 3570056 Storage Temp.: 0-10°C
Assay: >98.0%(HPLC) MF: 334.33
Highlight:

CAS 50-07-7 Mitomycin C

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Mitomycin C Antibiotic Raw Materials

 

CAS 50-07-7 Mitomycin C Antibiotic Raw Materials MF C15H18N4O5

 

Basic information
Product Name: Mitomycin C
CAS: 50-07-7
MF: C15H18N4O5
MW: 334.33
EINECS: 200-008-6
CAS 50-07-7 Mitomycin C Antibiotic Raw Materials MF C15H18N4O5 0
 
Mitomycin C Chemical Properties
Melting point 360 °C
Boiling point 471.14°C (rough estimate)
density 1.2238 (rough estimate)
refractive index 1.6800 (estimate)
storage temp. 2-8°C
solubility H2O: 4 mL/vial Stock solutions should be filter sterilized and stored at 2-8 °C in the dark., clear to slightly hazy, blue to purple
pka pKa 2.8(H2O,t =25,I=0.1) (Uncertain)
PH pH (0.5 g/l, 25℃ : )5.0～7.0
Water Solubility soluble
Merck 14,6215
BRN 7231816
Stability: Stable. Incompatible with strong acids, strong bases, strong oxidizing agents.
CAS DataBase Reference 50-07-7(CAS DataBase Reference)
IARC 2B (Vol. 10, Sup 7) 1987
EPA Substance Registry System Mitomycin C (50-07-7)
 
Safety Information
Hazard Codes T,Xn,T+
Risk Statements 25-40-22-45-26/27/28
Safety Statements 36/37-45-28A-28-53-22
RIDADR UN 3462 6.1/PG 2
WGK Germany 3
RTECS CN0700000
F 8-10
TSCA Yes
HazardClass 6.1(a)
PackingGroup II
HS Code 29419090
Hazardous Substances Data 50-07-7(Hazardous Substances Data)
Toxicity LD50 i.v. in mice: 5 mg/kg (Wakaki); also reported as 9 mg/kg (Kinoshita)

 

Uses (1) It is a cell division inhibitors, nucleic acid inhibitors and phage inducer; an anti-tumor drugs in clinical use.
(2) This drug has a broad anti-tumor spectrum, and effective for gastric cancer, breast cancer. It has a certain effect on lung cancer, liver cancer, malignant lymphoma, Hodgkin's disease, reticular cell sarcoma, uterine cancer, leukemia, intestinal cancer and pancreatic cancer, but with a short remission. Combination with urokinase can improve the efficacy. The goods exert its function quickly, but the number of operators is not high, and it has a high toxicity. The goods and bleomycin as well as its derivatives ——doxorubicin are anti-cancer drugs of antibiotic which can disrupt DNA. It can depolymerize DNA in the cell, inhibit DNA replication in proliferating cell. The LD50 of intravenous injection of mice is 5ml/kg. It acts as an anticancer drugs, commonly used in the treatment of digestive system cancers.
Description Mitomycin C is naturally produced by Streptomyces caespitosus, an Actinobacteria found in soil. Mitomycin C has antibiotic and antitumor activities and has been studied extensively since the 1950s. A unique feature of this drug is strong bioreductive alkylation under hypoxic conditions. Oxygen-poor cells internal to solid tumors provide an environment in which this drug is highly activated. As an antitumor agent, it has shown efficacy in a wide variety of cancers, including gastric cancer, pancreatic cancer, breast cancer, non-small-cell lung cancer, cervical cancer, prostate cancer, and bladder cancer. The sideeffect profile is large, which prohibits its widespread use. Mitomycin C is antibacterial to gram-positive, gram-negative, and acid-fast bacilli.
Chemical Properties Blue-violet crystals or crystalline powder.

Tag:

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