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Product Details:
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| Product Name: | Arbutin | CAS: | 497-76-7 |
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| Color: | White | Form: | Powder |
| Storage Temp.: | Room Temp | ||
| High Light: | 98% Arbutin Cosmetic Raw Materials,CAS 497-76-7 Cosmetic Raw Materials |
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CAS 497-76-7 Arbutin 98% Cosmetic Raw Materials Water Soluble
| Arbutin Basic information |
| Product Name: | Arbutin |
| Synonyms: | 4-hydroxyphenyl-beta-d-glucopyranosid;beta-arbutin;Hydroquinone β-D-glucopyranoside;Arbutin (natural);4-HYDROXYPHENYL-BETA-D-GLUCOPYRANOSIDE;4-(β-D-Glucopyranosyloxy)phenol;arbutin,beta-arbutin;4-hydroxyphenyl β-D-galactopyranoside |
| CAS: | 497-76-7 |
| MF: | C12H16O7 |
| MW: | 272.25 |
| EINECS: | 207-850-3 |
| Mol File: | 497-76-7.mol |
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| Arbutin Chemical Properties |
| Melting point | 195-198 °C |
| alpha | -64 º (c=3) |
| Boiling point | 375.31°C (rough estimate) |
| density | 1.3582 (rough estimate) |
| refractive index | -65.5 ° (C=4, H2O) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | H2O: 50 mg/mL hot, clear |
| form | neat |
| pka | 10.10±0.15(Predicted) |
| color | White |
| optical activity | [α]/D -64.0±2.0°, c = 3 in H2O |
| Water Solubility | 10-15 g/100 mL at 20 ºC |
| Sensitive | Hygroscopic |
| Merck | 14,773 |
| BRN | 89673 |
| Stability: | Stable. Hygroscopic - store under dry nitrogen. |
| InChIKey | BJRNKVDFDLYUGJ-RMPHRYRLSA-N |
| Safety Information |
| Hazard Codes | Xn |
| Risk Statements | 20/21/22-36/37/38 |
| Safety Statements | 22-24/25-36-26 |
| WGK Germany | 3 |
| RTECS | CE8863000 |
| F | 3-10-23 |
| HS Code | 29389090 |
| Hazardous Substances Data | 497-76-7(Hazardous Substances Data) |
| Description | Arbutin is a β-D-glucopyranoside HQ derivative and a plant-derived compound found in the dried leaves of several plant species, including blueberry, cranberry, bearberry, and pear trees. It suppresses tyrosinase activity without altering RNA expression. |
| Description | Arbutin is a glycosylated hydroquinone that has been found in Arctostaphylos plants and has diverse biological activities, including tyrosinase inhibitory, antioxidant, and anti-inflammatory properties. It inhibits human tyrosinase activity in crude tyrosinase solution isolated from human melanocytes (IC50s = 5.7 and 18.9 mM using L-tyrosine and L-DOPA as substrates, respectively) as well as in intact melanocytes (IC50 = 0.5 mM). Arbutin (50 μM) inhibits hemolysis induced by the free radical generator AAPH in sheep erythrocytes and inhibits AAPH-induced decreases in cell viability in cultured human skin fibroblasts when used at concentrations greater than 125 μM. In an LPS-induced rat model of acute lung injury, arbutin (50 mg/kg) prevents increases in IL-1β, IL-6, and TNF-α levels in lung tissue and serum. Formulations containing arbutin have been used in the treatment of hyperpigmentation disorders. |
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