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Product Details:
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| Product Name: | Methyl Sulfoxide | CAS: | 67-68-5 |
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| Form: | Liquid | Color: | Clear Colorless |
| Storage Temp.: | Room Temp | ||
| Highlight: | DMSO Dimethyl Sulfoxide Liquid 99.99％,CAS 67-68-5 DMSO |
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CAS 67-68-5 DMSO Dimethyl Sulfoxide Liquid 99.99％ Clear Colorless Chemical
| Dimethyl sulfoxide Basic information |
| Product Name: | Dimethyl sulfoxide |
| Synonyms: | sulfinylbis (methane);DMSO;DIMETHYL SULFOXIDE;DIMETHYL SULPHOXIDE;DIMETHYLIS SULFOXIDUM;FEMA 3875;Methyl sulfoxide, extra pure, 99.85%;Methyl sulfoxide, for analysis ACS, 99.9+% |
| CAS: | 67-68-5 |
| MF: | C2H6OS |
| MW: | 78.13 |
| EINECS: | 200-664-3 |
| Mol File: | 67-68-5.mol |
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| Dimethyl sulfoxide Chemical Properties |
| Melting point | 18.4 °C |
| Boiling point | 189 °C(lit.) |
| density | 1.100 g/mL at 20 °C |
| vapor density | 2.7 (vs air) |
| vapor pressure | 0.42 mm Hg ( 20 °C) |
| FEMA | 3875 | METHYLSULFINYLMETHANE |
| refractive index | n |
| Fp | 192 °F |
| storage temp. | Store at +5°C to +30°C. |
| solubility | H2O: miscible (completely) |
| pka | 35(at 25℃) |
| form | liquid (temperature dependent) |
| color | clear colorless |
| Relative polarity | 0.444 |
| Odor | Mild garlic odor |
| explosive limit | 1.8-63.0%(V) |
| Water Solubility | Soluble in water, methanol, acetone, ether, benzene, chloroform. |
| FreezingPoint | 18.4℃ |
| Sensitive | Hygroscopic |
| λmax | λ: 285 nm Amax: ≤0.20 λ: 295 nm Amax: ≤0.20 |
| JECFA Number | 507 |
| Merck | 14,3259 |
| BRN | 506008 |
| Stability: | Stable. Incompatible with a very wide range of materials, including acid chlorides, strong acids, strong oxidizing agents, strong reducing agents, phosphorus halides, moisture, copper wool + trichloroacetic acid. Reacts violently with a number of materials - consult a full data sheet before use. Hygroscopic. |
| InChIKey | IAZDPXIOMUYVGZ-UHFFFAOYSA-N |
| CAS DataBase Reference | 67-68-5(CAS DataBase Reference) |
| NIST Chemistry Reference | Dimethyl sulfoxide(67-68-5) |
| EPA Substance Registry System | Dimethyl sulfoxide (67-68-5) |
| Safety Information |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 24/25-37/39-26-36-23 |
| RIDADR | NA 1993 / PGIII |
| WGK Germany | 1 |
| RTECS | PV6210000 |
| F | 3 |
| Autoignition Temperature | 215 °C |
| TSCA | Yes |
| HS Code | 29309070 |
| Hazardous Substances Data | 67-68-5(Hazardous Substances Data) |
| Toxicity | LD50 orally in rats: 17.9 ml/kg (Bartsch) |
| Dimethyl sulfoxide Usage And Synthesis |
| Overview | Dimethyl sulfoxide (abbreviated DMSO) is a sulfur-containing organic compound; molecule formula: (CH3) 2SO; It exhibits as colorless, odorless, hygroscopic and flammable transparent liquid at room temperature. It has both high polarity as well as high-boiling point. It also has aprotic and water-miscible characteristics. It has low toxicity, good thermal stability, and is not miscible with paraffin. It is soluble in water, ethanol, propanol, ether, benzene and chloroform and many other kinds of organic substance and is called as the "universal solvent." It is a common organic solvent which has the strongest dissolving ability. It can dissolve most the organic compounds including carbohydrates, polymers, peptides, as well as many inorganic salts and gases. It can dissolve certain amount solute whose weight is equals to 50-60% of itself (other common solvents usually only dissolve 10-20%), so it is very important in the sample management as well as high-speed screening of drugs. Under certain conditions, contact between dimethyl sulfoxide and chloride can even lead to explosive reaction. dimethyl sulfoxide is widely used as solvents and reagents, particularly as the processing reagent and spinning solvent at the reaction of acrylonitrile polymerization used for polyurethane synthesis and the spinning solvent. It can also be used as the synthetic solvent for polyamide, polyimide and polysulfone resin as well as the extraction solvents for aromatic hydrocarbon and butadiene extraction solvents and solvents for synthesizing chlorofluoroaniline. In addition, dimethyl sulfoxide can also be directly used as the raw material or carrier of some drug in the pharmaceutical industry. dimethyl sulfoxide itself has various effects such as anti-inflammatory, analgesic, diuretic, and sedative, and thus also being known as "panacea" which is usually as the active ingredient of analgesic medication being added to the drug. It also has special properties of easy penetration through the skin, resulting in personnel feeling of oyster-like flavor. The dimethyl sulfoxide solution of sodium cyanide can cause cyanide poisoning through skin contact while dimethyl sulfoxide itself has a relative low toxicity. dimethyl sulfoxide is widely applied as the extraction agent in a lot of chemical and pharmaceutical companies. However, because of its higher boiling point, it causes very high operating temperatures and further causes the coking of materials, thus affecting the recycling of dimethyl sulfoxide and further cleaning of the equipments as well as resulting in increased energy consumption. Therefore, the recycling of dimethyl sulfoxide has become a bottleneck as its further wide application as extraction agent. The above information is edited by the Chemicalbook of Dai Xiongfeng. |
| Method of purification and water removal | dimethyl sulfoxide can be mixed with water and can be placed for long term storage and drying through molecular sieve. Further apply it to vacuum distillation and collect the fraction of 76 °C/1600Pa (12mmHg). Upon distillation, keep the temperatures at below 90 °C; otherwise it will result in disproportionation reaction which generates dimethyl sulfone and dimethyl sulfide. It may also be dried through calcium oxide, calcium hydroxide, barium oxide and barium sulfates and then distilled under reduced pressure. It may also be purified through partially crystallization. It can lead to explosion when mixing the dimethyl sulfoxide with certain substance such as sodium hydride, periodic acid or magnesium perchlorate, and thus should be paid attention. |
| Identification and detection methods | [Identification] Take 1.5 mL of this product and add to it slowly of 2.5 mL cooled hydroiodic acid drop wise; rapidly filter it and dry it under reduced pressure with the residue being unstable dark purple crystalline solid which has an unpleasant smell. Dissolving it in chloroform will form a red solution. [Check] Optical absorption, take certain amount of this product, pour through the stream of dry nitrogen for 15 minutes and immediately place it in 1cm absorption cuvette with water as a blank. Measure the absorbance of 275 nm according to spectrophotometric method (Chinese Pharmacopoeia 1990 edition of Appendix page 24) with a value being not higher than 0.30; and then further measure absorbance at wavelength of 285nm and 295nm with its ratio over that of the absorbance of 275nm being not greater than 0.65 and 0.45, respectively. Also note that, there should be no maximal absorption in the 270~350nm range. The water content should not exceed 0.2% (Chinese Pharmacopoeia 1990 edition of Appendix 55). Dimethyl sulfone take diphenyl methane to make a 0.025% acetone solution as the internal standard solution; accurately weigh appropriate amount of dimethyl sulfoxide and dilute to 0.050% solution of internal standard solution as the control solution; in addition, accurately weigh certain amount of this product and dilute to 50% solution with internal standard solution as the test solution. According to gas chromatography protocol (Chinese Pharmacopoeia 1990 edition, second volume, appendix page 31(3)), use 20 mM of 10% (coating concentration) polyethylene glycol as the fixer liquid; (the theoretical plate number calculated from dimethyl should be greater than 1500, and the separation degree of dimethyl sulfoxide peak and the internal standard peak should be greater than 2). The measured ratio of dimethyl sulfone peak area and diphenyl methane peak area of the sample solution at a column temperature of 150 °C should not be greater than that of the control solution. |
| Reference quality standards | For external use-DMSO quality of technical indicators Content, GC,%, ≥ 99.9 GB/2307-1986) Gas Chromatography IR identification, qualified EP Chemical identification, qualified EP Crystallization point, °C ≥ 18.3 GB/T7533-1993 The refractive index of 1.478-1.479 GB/T6488-1986 Moisture,%, KF, ≤ 0.2 GB/T6283-1986 UV extinction values, 275nm ≤ 0.3 GB 9721-1988 285nm ≤ 0.2 295nm ≤ 0.2 Heavy metals, PPm ≤ 10 GB/7532-1987 Specific gravity (20 ℃), 1.100-1.104 GB/4472-1984 Acidic value (0.1N/ml NaOH/50g), ≤ 5.0 GB/9736-1988 Packaging: PE plastic bucket Anhydrous-Technical index of DMSO quality Content (DMSO), GC%, ≥ 99.9 GB/2307---1986) Gas Chromatography Crystal point, °C, ≥ 18.35 GB/T7533-1993 Acidic value mgKOH/g, ≤ 0.001 GB/T9736-1988 Refractive index (20 °C), 1.478-1.479 GB/6488---1986 Moisture,%, KF, ≤ 0.001 GB/6283--1986 Evaporation residue, PPM, ≤ 5. GB/T3209----82 Heavy metals,%, ≤ 10. GB/T7532----87 Package: PE plastic bucket |
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