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Product Details:
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| Name: | EGTA | Cas No: | 67-42-5 |
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| Application: | Bioreagent | Purity: | 98% |
| Classification: | Biological Buffer | Form: | Powder |
| Color: | White To Slightly Off-white | Package: | 1kg/5kg/25kg |
| Transport: | Courier/Air/Sea | Samples: | Available |
| Highlight: | EGTA Biological Buffers,Egtazic Acid Biological Buffers,CAS 67-42-5 |
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EGTA CAS 67-42-5 ethylene glycol bis(2-aminoethyl)tetraacetic acid
EGTA is a specific calcium ion chelator. EGTA has an apparent calcium dissociation constant (Kd) of 60.5 nM at physiological pH (7.4) and has very high specificity for Ca2+ over Mg2+ (Mg2+ Kd 1-10 mM). EGTA significantly inhibited the substrate adherence capacity of inflammatory macrophages[1][2].
| Ethylenebis(oxyethylenenitrilo)tetraacetic acid Basic information |
| Product Name: |
Ethylenebis(oxyethylenenitrilo)tetraacetic acid |
| Synonyms: | 3,6-DIOXAOCTAMETHYLENEDINITRILOTETRAACETIC ACID;1,2-bis(2-dicarboxymethylaminoethoxy)ethane;12-diazatetradecanedioicacid,3,12-bis(carboxymethyl)-9-dioxa-3;6,9-Dioxa-3,12-diazatetradecanedioicacid,3,12-bis(carboxymethyl)-;9-Dioxa-3,12-diazatetradecanedioicacid,3,12-bis(carboxymethyl)-6;ebonta;ethylenedioxybis(ethyleneamino)tetraaceticacid;ETHYLENE GLYCOL BIS-(BETA-AMINOETHYLETHER)-N,N,N',N'-TETRAACETIC |
| CAS: | 67-42-5 |
| MF: | C14H24N2O10 |
| MW: | 380.35 |
| EINECS: | 200-651-2 |
| Product Categories: | Analytical Chemistry;Chelating Reagents;Complexones;EDTA Analogs |
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| Ethylenebis(oxyethylenenitrilo)tetraacetic acid Chemical Properties |
| Melting point | 241 °C (dec.)(lit.) |
| Boiling point | 507.99°C (rough estimate) |
| density | 1.2838 (rough estimate) |
| refractive index | 1.4590 (estimate) |
| storage temp. | room temp |
| solubility | 0.1 M NaOH: 0.1 M at 20 °C, clear, colorless |
| pka | 1.47±0.10(Predicted) |
| form | Crystalline Powder |
| color | White |
| Water Solubility | slightly soluble |
| Merck | 14,3529 |
| BRN | 1717370 |
| CAS DataBase Reference | 67-42-5(CAS DataBase Reference) |
| EPA Substance Registry System |
Ethylenebis(oxyethylenenitrilo)tetraacetic acid (67-42-5) |
| Safety Information |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 24/25-36-26 |
| WGK Germany | 2 |
| RTECS | AH3760000 |
| TSCA | Yes |
| HS Code | 29225000 |
| Toxicity | LD50 orally in Rabbit: 3587 mg/kg |
| Ethylenebis(oxyethylenenitrilo)tetraacetic acid Usage And Synthesis |
| Description |
Ethylenebis(oxyethylenenitrilo)tetraacetic acid is also named as Egtazic acid. It works as a chelating agent for the determination of calcium in the presence of magnesium. |
| Chemical Properties |
White to slightly off-white powder |
| Uses | Pharmaceutic aid. EGTA. |
| Uses | Ethylene glycol-O,O'-bis(2-aminoethyl)-N,N,N',N'-tetraacetic acid is a chelating agent used for making complexes, especially for calcium ions, which help to determine calcium in the presence of magnesium. It can be used experimentally for treating animals possessing cerium poisoning. It is useful in the separation of thorium from monazite. It also acts as a buffer and is used in protein purification. |
| Uses | A chelating agent useful for the determination of calcium in the presence of magnesium. |
| Definition | ChEBI: A diether that is ethylene glycol in which the hydrogens of the hydroxy groups have been replaced by 2-[bis(carboxymethyl)amino]ethyl group respectively. |
| Biological Activity | Calcium chelator; protects against cell death caused by nitric oxide-induced calcium influx into nerve cells. |
| Safety Profile | Poison by intraperitoneal route. Moderately toxic by ingestion. When heated to decomposition it emits toxic fumes of NOx. See also GLYCOL ETHERS. |
| Purification Methods | Dissolve EGTA in aqueous NaOH, precipitate it by adding aqueous HCl, wash it with water and dry at 100o in vacuo.[Beilstein 4 IV 217.] |
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